Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial (CAF-PINT)
Completed
Conditions studied: Heart Failure, Respiratory Failure
In brief
Project Summary We propose an ancillary study to The Heart and Lung Failure Pediatric Insulin Titration trial (HALF PINT), which is investigating the impact of normalizing blood glucose using insulin infusions on clinical outcomes among children with hyperglycemia and heart and lung failure. In this ancillary study, we will measure plasma levels of inflammatory, coagulation, and fibrinolysis proteins and genotype DNA for polymorphisms among patients enrolled in the HALF PINT trial. The results from this ancillary study will help us to understand potential mechanisms through which normalizing blood glucose provides benefit, which may lead to development of new therapeutic strategies in critically ill children
Key facts
- Study ID
- NCT01892969
- Run by
- University of California, San Francisco
- People needed
- 304
- Starts
- 2012-10-01
- Expected to finish
- 2016-09-01
- Last updated by the study team
- 2020-07-31
Who can join
Age: 0 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All Patients enrolled in the HALF PINT trial
You may not qualify if…
- Bleeding Diathesis as manifest by a Most Recent recorded International Normalized ratio (INR) >3
Where it is running
- Children's Hospital of Los Angeles — Los Angeles, California, United States
- Mattel Children's Hospital (UCLA) — Los Angeles, California, United States
- Children's Hospital and Research Center of Oakland — Oakland, California, United States
- Children's Hospital of Orange County — Orange, California, United States
- Children's Hospital Colorado - Denver — Aurora, Colorado, United States
- Yale - New Haven Children's Hospital — New Haven, Connecticut, United States
- Nemours/Alfred I. DuPont Hospital for Children — Wilmington, Delaware, United States
- Children's Healthcare of Atlanta (Emory) — Atlanta, Georgia, United States
- Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
- University of Chicago Medicine Comer Children's Hospital — Chicago, Illinois, United States
- Indiana University Riley Hospital for Children — Indianapolis, Indiana, United States
- University of Louisville Children's Hospital — Louisville, Kentucky, United States
- Children's Hospital of Boston — Boston, Massachusetts, United States
- C.S. Mott Children's Hospital - Michigan — Ann Arbor, Michigan, United States
- St. Louis Children's Hospital — St Louis, Missouri, United States
- Dartmouth Hitchcock Medical Center — Manchester, New Hampshire, United States
- Women and Children's Hospital of Buffalo — Buffalo, New York, United States
- Cohen Children's Medical Center of NY/ North Shore LIJ — New Hyde Park, New York, United States
- Maria Fareri Children's Hospital at Westchester Medical Center — Valhalla, New York, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- PennState Hershey Medical Center — Hershey, Pennsylvania, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Medical City Children's Dallas — Dallas, Texas, United States
- Children's Medical Center Dallas — Dallas, Texas, United States
- Primary Children's Medical Center — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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