A Randomized Controlled Trial of Eculizumab in AQP4 Antibody-positive Participants With NMO (PREVENT Study)
Stopped early · Phase 3 · Has a placebo group
Conditions studied: Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder
In brief
The objectives of this time-to-event study were to assess the efficacy and safety of eculizumab as compared with placebo in participants with neuromyelitis optica spectrum disorder (NMOSD) who were anti-aquaporin-4 (AQP4) antibody-positive.
Key facts
- Study ID
- NCT01892345
- Run by
- Alexion Pharmaceuticals, Inc.
- People needed
- 143
- Starts
- 2014-04-11
- Expected to finish
- 2018-07-17
- Last updated by the study team
- 2019-06-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- The Research Center of Southern California — Carlsbad, California, United States
- Georgetown University Hospital — Washington D.C., District of Columbia, United States
- University of Miami McKnight Brain Institute — Miami, Florida, United States
- Neurological Services of Orlando — Orlando, Florida, United States
- Fort Wayne Neurological Center — Fort Wayne, Indiana, United States
- University of Kansas Medical Center — Kansas City, Kansas, United States
- Baptist Health Lexington — Lexington, Kentucky, United States
- University of Maryland Medical Center — Baltimore, Maryland, United States
- John Hopkins University School of Medicine — Baltimore, Maryland, United States
- Mayo Clinic - Rochester — Rochester, Minnesota, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- Multiple Sclerosis Comprehensive Care Center, NYU Langone Medical Center — New York, New York, United States
- The Ohio State University, Wexner Medical Center, CarePoint at Gahanna — Gahanna, Ohio, United States
- Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States
- Multiple Sclerosis Treatment Center of Dallas — Dallas, Texas, United States
- University of Utah Health Care — Salt Lake City, Utah, United States
- Swedish Neuroscience Institute — Seattle, Washington, United States
- Hospital General de Agudos Juan Antonio Fernandez — Ciudad Autonoma, Buenos Aires, Buenos Aires, Argentina
- Hospital J. M. Ramos Mejia — Ciudad Autonoma, Buenos Aires, Buenos Aires, Argentina
- Hospital Universitario Austral — Pilar, Buenos Aires, Argentina
- Fundacion Rosarina de Neuro Rehabilitacion — Rosario, Santa Fe Province, Argentina
- University of Sydney, Brain and Mind Center — Camperdown, New South Wales, Australia
- St. Vincent's Hospital Melbourne — Fitzroy, Victoria, Australia
- Mayo Clinic Arizona — Scottsdale, Arizona, United States
Full record on ClinicalTrials.gov
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