Evaluating Two Types of Cognitive Training in Veterans With Schizophrenia

Completed · Not applicable · Has a placebo group

Conditions studied: Schizophrenia

In brief

Cognitive dysfunction is a major contributor to the poor community outcome of individuals with schizophrenia. Developing more effective cognitive remediation interventions is imperative to improve the daily lives of affected subjects and reduce the disability of this illness. The goal of this clinical trial is to evaluate two types of cognitive training approaches to determine which one is more beneficial for individuals with schizophrenia. This study also uses electrophysiological techniques to gain a better understanding of the mechanisms involved in cognitive remediation. Findings from this study will provide information about how to design the most optimally efficient cognitive training intervention to improve the cognitive and social functioning of patients with severe mental illness.

Key facts

Study ID

NCT01891721

Run by

VA Office of Research and Development

People needed

105

Starts

2013-11-21

Expected to finish

2018-06-30

Last updated by the study team

2019-08-14

Who can join

Age: 25 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Veterans with a Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) diagnosis of schizophrenia or schizoaffective disorder
• Between 25 and 65 years of age
• Estimated premorbid inteIligence quotient (IQ) > 70 (based on reading ability)
• Understand spoken English sufficiently to comprehend the consent form
• Clinically stable (i.e., no inpatient hospitalization in the 3 months, no changes in psychiatric medications in the 6 weeks, and no changes in housing in the 2 months, prior to enrollment)

You may not qualify if…

• Documented history of mental retardation or severe learning disability
• Clinically significant neurological disease as determined by medical history (e.g., epilepsy, stroke)
• History of serious head injury with loss of consciousness greater than 1 hour and concomitant neuropsychological sequelae
• Meeting DSM-IV criteria for drug or alcohol dependence during the 6 months, or abuse during the month preceding study enrollment

Where it is running

• Local Board and Care Facilities — Los Angeles, California, United States
• VA Greater Los Angeles Healthcare System, West Los Angeles, CA — West Los Angeles, California, United States

Full record on ClinicalTrials.gov

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