Exercise Effects on Insulin, Gut Peptides, and Appetite
Completed · Not applicable
Conditions studied: Endocrine and Metabolic Responses to Exercise and Diets
In brief
Determine whether the mid-day suppression of hunger and amplified increase in the release of glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide 1 (GLP-1) following morning exercise is due to increased fat content of the diet per se or a combination of high fat diet after morning exercise. The action of gut peptides, particularly GLP-1, on gastric emptying is likely to be important in mediating its effects on postprandial appetite and glycemia (Nauck et al. 1997). Our hypothesis is that exercise amplifies gut peptide secretion when diet is enriched with fat, and that this stimulus suppresses the hunger sensation.
Key facts
- Study ID
- NCT01891617
- Run by
- University of Michigan
- People needed
- 16
- Starts
- 2010-11-01
- Expected to finish
- 2013-03-01
- Last updated by the study team
- 2016-06-13
Who can join
Age: 50 and older, up to 65. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Postmenopausal status
- Age 50 to 65 years
- BMI between 20 and 30 kg/m2.
- Good health status (normotensive, fasting glucose < 100 mg/dl, , hematocrit > 32%, hemoglobin >12 mg/dl)
- Absence of restricted food intake
- Absence of endocrine and metabolic disorders requiring medication other than hormonally corrected hypothyroidism
- Absence of musculoskeletal disabilities that would prevent walking
You may not qualify if…
- Presence of endocrine and metabolic disease requiring medication, other than hormonally corrected hypothyroidism
- Presence of musculoskeletal disabilities that would prevent walking
- Smoking
- Active dieting
- Absence of listed inclusion criteria
- Unwillingness to follow study protocol.
Where it is running
- Michigan Clinical Research Unit — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
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