Gluconeogenesis Rates and Its Precursors in Pediatric Sepsis
Completed
Conditions studied: Sepsis, Hyperglycemia, Critical Illness
In brief
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Often sick children have increased glucose concentrations in blood. However, the origin of the high glucose has not been determined in these populations. There is a close interrelationship between protein and energy metabolism. An increase in the energy supply will not promote nitrogen retention unless the amino acid supply is adequate, and conversely, an increased amino acid supply will be useless if energy is limiting, hence the importance of adequate protein and energy intake. Our study aims to investigate the protein-energy interactions in critically ill septic children and adolescents with the objective to eventually provide the best nutritional support for these patients.
Key facts
- Study ID
- NCT01890928
- Run by
- The Cleveland Clinic
- People needed
- 19
- Starts
- 2011-03-01
- Expected to finish
- 2013-10-01
- Last updated by the study team
- 2016-04-28
Who can join
Age: 5 and older, up to 19. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Children age 5-19 years.
- Diagnosis of severe sepsis diagnosed as clinical sepsis syndrome (requires two of the following criteria):
- Source of infection
- Fever or Hypothermia
- Leukocytosis or Leucopenia
- Poor organ perfusion (such as delayed capillary refill or decreased urine output or hypotension)
- Bacteremic sepsis demonstrated by positive blood culture
- Indwelling central and/or arterial venous access as per clinical indication.
You may not qualify if…
- Patients with metabolic diseases (i.e.: urea cycle disorders, cystinuria, Insulin dependent diabetes mellitus, etc.).
- Pregnancy.
- Primary liver failure.
- Healthy Children:
- Inclusion Criteria:
- Age 13-19 years.
- Evidence of health as assessed by physical exam, and laboratory tests, including: Hematocrit no less than 36% for males and no less than 37% for females, white blood cell count from 5-10,000.
- Chemistries within normal range, normal urine analysis, and fasting plasma glucose level no less than 60 or greater than 104 mg/dL.
- Lean Children with BMI of 18-24.
- Obese Children with BMI of 30 or greater.
- Exclusion Criteria:
- Tobacco use.
- Pregnancy.
- Taking any prescription medication that affects amino acid metabolism, i.e., glucocorticoids.
- History of acute or chronic illness.
Where it is running
- UT Southwestern Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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