Fat Metabolism Following Chemotherapy in Breast Cancer
Stopped early
Conditions studied: Breast Cancer
In brief
Following chemotherapy, breast cancer patients primarily gain fat mass and lose muscle mass. Both depletion of muscle and an increase of fat mass in breast cancer patients are related to short survival, and decreased skeletal muscle mass and function may result in fatigue and inactivity, which contributes to fat mass changes and can be responsible for chemo-toxicity and increased mortality. The purpose of this study is to provide detailed insight in chemotherapy related changes in lipid metabolism and gut digestion and absorption of fat in breast cancer patients compared to matched healthy controls. This will provide required information that is necessary to implement new strategies to develop optimal nutritional regimen in breast cancer patients. The hypothesis is that chemotherapy in breast cancer is related to altered gut function and absorption and to increases in fat synthesis that lead to fat accumulation. In addition, we will examine the effect of cancer, chemotherapy, and gender by comparing fat digestion/absorption and fat metabolism of the breast cancer before and after chemotherapy, to aged matched healthy female and male controls.
Key facts
- Study ID
- NCT01890824
- Run by
- Texas A&M University
- People needed
- 5
- Starts
- 2013-08-01
- Expected to finish
- 2015-10-01
- Last updated by the study team
- 2016-02-03
Who can join
Age: 30 and older. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Presence of fever within the last 3 days
- Untreated metabolic diseases including hepatic or renal disorder
- Presence of acute illness or metabolically unstable chronic illness
- Use of nutritional supplements within 5 days of first test day
- Any other condition according to the PI or nurse that would interfere with the study or safety of the patient
- Failure to give informed consent
- Possible) pregnancy
Where it is running
- Texas A&M University — College Station, Texas, United States
Full record on ClinicalTrials.gov
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