Chronic Kidney Disease in Relation to Alterations in Protein and Amino Acid Metabolism and Function

Withdrawn before enrolling · Not applicable

Conditions studied: Chronic Kidney Failure

In brief

Weight loss commonly occurs in patients with chronic kidney disease (CKD), negatively influencing their quality of life, treatment response and survival. Loss of muscle protein is generally a central component of weight loss in CKD patients but patients also have reductions in fat mass and bone density, independent of the severity of the disease state. Attempts to reverse weight and muscle loss in CKD and improve nutritional status by nutritional supplementation have been unsuccessful and there are currently no approved therapies. Purpose of this study is to provide detailed insight in disease related gut function by obtaining information on gut permeability, digestion and absorption of glucose, fat and protein in CKD patients compared to matched healthy controls. Additionally, to examine whether protein and amino acid metabolism is disturbed in CKD patients compared to healthy controls. This will provide required information that will lead to implement new strategies to develop optimal nutritional regimen in order to enhance nutritional status, quality of life and survival in relation to kidney disease.

Key facts

Study ID
NCT01890811
Run by
Texas A&M University
People needed
0
Starts
2013-06-01
Expected to finish
2016-12-01
Last updated by the study team
2015-05-01

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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