Phase II Trial of Conventional Versus IMRT Whole Brain Radiotherapy for Brain Metastases
Status unconfirmed · Not applicable
Conditions studied: Metastatic Brain Cancer
In brief
In this study the patient will receive either whole brain radiation therapy given by intensity modulated radiation therapy (IMRT) or standard conventional radiation. In IMRT therapy radiation dose to the parts of the brain that do not contain tumors is reduced. This study will look to see if this approach results in less hair loss or fewer memory Problems, as compared to the standard technique. The study will also look at the effectiveness of both techniques in controlling the growth of the tumor.
Key facts
- Study ID
- NCT01890278
- Run by
- Good Samaritan Hospital Medical Center, New York
- People needed
- 60
- Starts
- 2013-06-01
- Expected to finish
- 2017-03-01
- Last updated by the study team
- 2013-07-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Evidence of at least one brain metastasis on a gadolinium contrast-enhanced MRI
- Pathologic/histological/cytologic proof of a diagnosis of a non-hematopoietic malignancy within 5 years of study entry.
- Patient ≥18 years of age?
- Fall into RTOG Recursive Partition Analysis (RPA) class I or II.
- Karnofsky Performance Score ≥70. (See Appendix III)
- Biopsy done at least 1 week prior to registration. (This requirement does not apply to stereotactic biopsies.)
You may not qualify if…
- Contraindication to MR imaging such as implanted metal devices or foreign bodies, severe claustrophobia.
- Creatinine level > 1.4 mg/dl drawn ≤30 days prior to study entry.
- Severe, active co-morbitities.
- Unstable angina, and/or congestive heart failure requiring hospitalization within the last 6 months.
- Transmural myocardial infarction within the last 6 months
- Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
- Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects
- Uncontrolled, clinically significant cardiac arrhythmias
- Pregnancy
Where it is running
- Good Samaritan Hospital Medical Center — West Islip, New York, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.