Repeatability and Reproducibility of Cirrus HD-OCT Measurements of Illumination Areas Under the Retinal Pigment Epithelium

Completed

Conditions studied: Advanced Dry AMD With Geographic Atrophy

In brief

The objective of this study is to determine the repeatability and reproducibility of the Cirrus HD-OCT measurement of illumination areas under the retinal pigment epithelium (RPE).

Key facts

Study ID

NCT01890187

Run by

Carl Zeiss Meditec, Inc.

People needed

85

Starts

2010-11-01

Expected to finish

2011-02-01

Last updated by the study team

2013-07-01

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females 50 years of age and older diagnosed to have advanced dry AMD with geographic atrophy.
• Geographic atrophy lesions should:
• Not be greater than 5 mm at the widest diameter. The entire lesion(s) should fit into the 6x6 mm scan area of the Cirrus HD-OCT.
• Not be smaller than 1.25 mm2.
• Not be confluent with peri-papillary atrophy.
• Not be combined with other lesions such as CNV.
• Able and willing to make the required study visits.
• Able and willing to give consent and follow study instructions.

You may not qualify if…

• History of retinal surgery, laser photocoagulation, and/or radiation therapy to the eye.
• Evidence of other retinal diseases of the eye, including wet AMD, diabetic retinopathy, diabetic macular edema, or significant vitreomacular traction.
• Thick media opacity or inability to fixate that precludes obtaining acceptable scans.
• Concomitant use of hydrochloroquine or chloroquine.
• Unable to make the required study visits.
• Unable to give consent or follow study instructions.

Where it is running

• West Coast Retina — Walnut Creek, California, United States

Full record on ClinicalTrials.gov

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