Text Messaging to Improve Adherence to Oral Chemotherapy Agents

Completed · Not applicable

Conditions studied: Cancer

In brief

The purpose of this Academic Research Enhancement Award proposal is to conduct a small-scale health-related research project on text messages to improve adherence to oral chemotherapy agents. Michigan State University College of Nursing has not been a major recipient of National Institute of Health grant funding. As a result, the overall objective of this proposal is to strengthen the research environment in the College of Nursing so that it can develop into a significant health-related scientific research enterprise. This project would involve undergraduate and graduate students, and thus, generate student interest in research as a career. The importance of the research planned for this proposal is as follows. More than 50 oral chemotherapy agents in pill form are currently on the market, with projections that in 3 years, 25% of cancer treatments will be delivered in pill form. For oral agents to achieve a therapeutically effective level for cancer treatment, patients must strictly adhere to the regimen. Adherence to oral cancer agents is often less than 80%, which may be inadequate for treating the cancer. To date, empirical research in the area of improving adherence to oral agents is underdeveloped. The goal of this research is to improve adherence to oral chemotherapy agents through a technology based strategy, tailored SMS text messages. This prospective randomized controlled trial will examine the feasibility, acceptability, and satisfaction with a 3-week tailored text message intervention for oral agent adherence. Descriptive statistics, generalized linear modeling, and generalized estimating equations will be used for analysis. In this proposal, preliminary data will be collected to examine efficacy of the text message intervention to promote adherence to oral agents. Data will then be used to further inform the development of an intervention to improve adherence to oral agents for an R01 application to conduct a larger randomized trial to test this innovative intervention. This study can have a transformative impact on oral agent adherence by developing a technology-based strategy to promote adherence among the increasing number of cancer patients who receive their cancer treatment in pill form. This type of novel intervention also has the potential to transform and impact many other ill populations that require adherence to a medication regimen.

Key facts

Study ID

NCT01889511

Run by

Michigan State University

People needed

75

Starts

2013-06-01

Expected to finish

2015-06-01

Last updated by the study team

2015-09-21

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with cancer
• Prescribed an oncolytic or therapeutic oral agent (non-hormonal)
• Able to speak, read, and understand English
• Able and willing to receive phone calls
• Has a personal cell phone, and able and willing to receive and send a text message

You may not qualify if…

• Deaf, blind, or unable hear, or unable to accept phone calls
• Prescribed hormonal therapy for cancer treatment

Where it is running

• Yale University — New Haven, Connecticut, United States
• Diplomat Specialty Pharmacy — Flint, Michigan, United States
• McLaren Cancer Institute — Flint, Michigan, United States
• Allegiance Health — Jackson, Michigan, United States
• Sparrow Hospital — Lansing, Michigan, United States
• Huron Medical Center — Port Huron, Michigan, United States

Full record on ClinicalTrials.gov

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