Effect of a Grape Seed Extract (GSE) on Insulin Resistance

Completed · Not applicable · Has a placebo group

Conditions studied: Metabolic Syndrome

In brief

In people with the metabolic syndrome, the investigators hypothesize that administration of a single 300 mg dose of a grape seed extract (GSE) will reduce insulin resistance (how well cells in the body can take up and use glucose), oxidative stress, and the amount of oxidized LDL in the blood during a 24 hour period. These measurements will be assessed at hourly intervals during the 24 hour study day protocol. Additionally, the investigators hypothesize that daily administration of 300 mg of GSE for 30 days will decrease baseline insulin resistance, oxidative stress, and the level of oxidized LDL in the blood.

Key facts

Study ID: NCT01889368
Run by: University of California, Davis
People needed: 19
Starts: 2012-11-01
Expected to finish: 2015-03-01
Last updated by the study team: 2017-06-27

Who can join

Age: 20 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Metabolic Syndrome, based on subject meeting at least 3 of the following criteria:
Abdominal obesity with waist circumference > 40 inches in men or > 35 inches in women,
Pre-hypertension with blood pressure > 135/85,
Fasting blood glucose levels above 110 mg/dl,
Plasma triglyceride levels in excess of 150 mg/dl,
HDL levels below 40 mg/dl in men or 50 mg/dl in women.

You may not qualify if…

Any known systemic disease,
Diabetes,
Alcohol consumption > 1-2 drinks/week,
Taking any medications or supplements that will affect metabolism, their ability to exercise or oxidative status,
Smokers,
Female subjects having abnormal menstrual cycles, taking oral contraceptives, pregnant or lactating.

Where it is running

VA Hospital, Mather — Mather, California, United States

Full record on ClinicalTrials.gov

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