Methionine Metabolism in Enterally Fed Pediatric Sepsis

Completed

Conditions studied: Sepsis, Critical Illness

In brief

Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Protein synthesis is increased mainly in the form of immune and signaling proteins, while muscle and structural protein synthesis is decreased. The metabolism of sulfur amino acids through the splanchnic area and specifically methionine and cysteine have not been investigated in critically ill septic children, despite that sulfur amino acids have important roles in thiol, antioxidant and epigenetic reactions. Methionine metabolism in sick children will be influenced by its rate of utilization through different pathways. Our study aims to investigate the metabolism of methionine and cysteine when both amino acids are given by the enteral route in critically ill septic children. The investigators are focused on the rates of transmethylation, remethylation and transsulfuration in critically ill septic children, and if the current standard nutrition maintains methionine nutritional balance and functional requirements in critically ill children fed by the enteral route.

Key facts

Study ID

NCT01889264

Run by

The Cleveland Clinic

People needed

45

Starts

2011-12-01

Expected to finish

2016-10-01

Last updated by the study team

2017-03-22

Who can join

Age: 0 and older, up to 19. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children age 1 month-19 years
• Diagnosis of severe sepsis diagnosed as clinical sepsis syndrome (requires two of the following criteria):
• Source of infection
• Fever or Hypothermia
• Leukocytosis or Leucopenia
• Poor organ perfusion (such as delayed capillary refill or decreased urine output or hypotension)
• Bacteremic sepsis demonstrated by positive blood culture
• Weight greater or equal to 4.0 kg
• Need for enteral nutrition by a nasogastric/nasoduodenal tube
• Presence of central and/or arterial venous access as per clinical indication

You may not qualify if…

• Patients with metabolic diseases (i.e. Insulin dependent diabetes mellitus, urea cycle disorders, cystinuria, etc.)
• Pregnancy
• Primary liver failure
• Primary renal failure
• Patients unable to tolerate enteral feedings
• Weight less than 4.0 kg

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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