Molecularly Tailored Therapy for Pancreas Cancer

Completed · Phase 2

Conditions studied: Pancreatic Cancer

In brief

Patient therapy is tailored according to the molecular profile of the patient's tumor.

Key facts

Study ID

NCT01888978

Run by

Georgetown University

People needed

19

Starts

2012-12-01

Expected to finish

2018-01-24

Last updated by the study team

2018-04-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically proven pancreatic adenocarcinoma with measurable disease
• Biopsy accessible tumor deposits
• ECOG performance status 0-2
• Age >/= 18 years
• Subjects with no brain metastases or history of previously treated brain metastases
• Adequate hepatic, renal, and bone marrow function
• Partial thromboplastin time must be </= 1.5 x upper normal limit of institution's normal range and INR < 1.5
• Life expectancy > 12 weeks
• Women of childbearing potential must have a negative seum pregnancy test within 14 days prior to initiation of treatment
• Subject is capable of understanding and complying with parameters as outlines in the protocol and able to sign and date the consents

You may not qualify if…

• CNS metastases which do not meet criteria outlines in inclusion criteria
• Active severe infection or known chronic infection with HIV or hepatitis B virus
• Cardiovascular disease
• Life threatening visceral disease or other severe concurrent disease
• Women who are pregnant, breastfeeding, or women of childbearing potential not using dual forms of effective contraception
• Anticipated patient survival under 3 months
• Patients receiving any other investigational agents
• History of allergic reactions attributed to compounds of similar chemical or biological composition to gemcitabine, oxaliplatin, 5-FU, docetaxel or irinotecan
• Uncontrolled intercurrent illness

Where it is running

• Georgetown University- Lombardi Comprehensive Cancer Center — Washington D.C., District of Columbia, United States
• MedStar Montgomery Medical Center — Olney, Maryland, United States

Full record on ClinicalTrials.gov

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