Effects of Interrupting Sedentary Behavior on Metabolic and Cognitive Outcomes in Children
Completed · Phase 1/Phase 2
Conditions studied: Healthy Volunteer
In brief
Background: \- Some studies in adults have found that insulin and glucose blood levels are lower when a long period of sitting is broken up with walking, compared to sitting without breaks. This means that the body can better process sugars when there are walking breaks during the day. Researchers want to know if this is also true for children. Some studies have found that children s attention and memory might be better after exercise. Researchers want to know if short walking breaks have the same effects. Objectives: \- To understand if breaking up sitting with walking helps children s bodies better use sugars and improves children s concentration. Eligibility: \- Healthy children ages 7 to 11. Design: * Participants will be screened with a physical exam, medical history, exercise test, picture vocabulary test, and medical tests including blood tests and X-rays. * Participants will return for two 7-hour visits. In the month before the visits, they will wear a physical activity monitor for one week so researchers know how active they are. Once they will take the sitting only test and once the sitting breaks test. * During the sitting only test, participants will sit for 3 hours. * During the sitting breaks test, they will sit for 3 hours with 3-minute walking breaks every 30 minutes. * Both days, they will drink sugar water. Then the participants will have blood drawn from a needle that is kept in place, and they will wear a heart monitor. They will take attention and working memory tests on a computer and answer questions about how they feel. They will eat a meal at the end of the test day.
Key facts
- Study ID
- NCT01888939
- Run by
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- People needed
- 89
- Starts
- 2013-06-26
- Expected to finish
- 2018-01-29
- Last updated by the study team
- 2018-01-31
Who can join
Age: 7 and older, up to 11. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Significant cardiac or pulmonary disease likely to or resulting in hypoxia or decreased perfusion.
- Evidence of impaired glucose tolerance or type 2 diabetes, including fasting plasma glucose greater than or equal to 100 mg/dL.
- Presence of other endocrinologic disorders leading to obesity (e.g.: Cushing Syndrome).
- Participants who have, or whose parent/guardians have, current substance abuse or a psychiatric disorder or other condition that, in the opinion of the investigators, would impede competence, compliance, or prevent the completion of the study.
- Participants who have, or are currently receiving, anti-psychotic drugs that would affect metabolism, cognitive outcomes, and body habitus.
- Participants receiving medical treatment other than diet for hypertension or dyslipidemia.
- Participants with precocious puberty and/or receiving androgen and estrogen therapy.
- Participants currently taking medications for ADHD, or any disorder or use of medications known to affect body composition or weight.
- Presence of pre-existing neurocognitive disabilities, or an age-adjusted score below 85 on the Picture Vocabulary Test at the screening visit.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.