Treatment of Suicidal Ideation With Intravenous Ketamine Infusion

Completed · Not applicable · Has a placebo group

Conditions studied: Depression, Suicidal Ideation

In brief

This study is dedicated to achieving better treatments for suicidal thoughts. Specifically, the investigators are studying the effect of a medication called ketamine to quickly treat suicidal thoughts and depression.

Key facts

Study ID

NCT01887990

Run by

University of Alabama at Birmingham

People needed

18

Starts

2012-05-01

Expected to finish

2014-01-01

Last updated by the study team

2017-05-15

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age : 19-64
• Significant suicidality score on the Columbia Suicide Severity Rating Scale (C-SSRS)
• Willing and able to provide informed consent.
• Individuals with current substance abuse are allowed

You may not qualify if…

• Pregnant or lactating; women of reproductive potential must have a negative urine pregnancy test (urine dipstick method)
• Post-Partum state : defined as being within 2 months of delivery or miscarriage
• Homicide risk as determined by clinical interview
• Treatment with any medication known to specifically target the glutamate-NMDA receptor system (ie lamotrigine, acamprosate, memantine, riluzole or lithium)
• Any known hypersensitivity or serious adverse effect associated with ketamine treatment.
• Any clinically significant medical condition or therapy that would preclude treatment with ketamine, to include recent myocardial infarction or unstable angina
• Medically unstable, including acute withdrawal from alcohol or benzodiazepines requiring the use of benzodiazepine treatment.
• Any of the following DSM-IV diagnoses or categories:
• Any current psychosis or history of a non-mood psychotic disorder (e.g., schizophrenia)
• Currently in a manic or mixed episode
• Current use (defined by urine dipstick test) or abuse of hallucinogenic drugs (except marijuana) such as phencyclidine
• Any dissociative disorder
• Any pervasive developmental disorder (e.g., autism)
• A cognitive disorder (e.g., Alzheimer's Disease)
• Cluster A personality disorder (e.g., schizoid or schizotypal); note that cluster B and C personality disorders may be included
• Any eating disorder

Where it is running

• University of Alabama Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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