Studying the Effects of Phentermine on Eating Behavior

Completed · Phase 4 · Has a placebo group

Conditions studied: Obesity

In brief

The goal of this study is to determine whether one week of phentermine compared to placebo administration results in changes in food intake during a laboratory meal.

Key facts

Study ID

NCT01886937

Run by

New York State Psychiatric Institute

People needed

13

Starts

2012-07-01

Expected to finish

2014-06-01

Last updated by the study team

2017-07-31

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• BMI between 30-40kg/m2
• Stable weight (+5 lbs) for a minimum of 3 months
• Systolic Blood Pressure <140mm Hg
• Diastolic Blood Pressure <90 mm Hg
• Pulse <95 beats per minute
• English language proficiency

You may not qualify if…

• Previous unsuccessful trial of phentermine
• Prior adverse reaction to phentermine
• On any antidepressant medications,especially monoamine oxidase inhibitors(MAOI)
• History of neurological disorder (e.g. dementia)
• History of moderate or severe head injury
• Current or past history of coronary artery disease
• Current or past history of stroke or transient ischemic attack
• Current or past history of heart arrhythmias
• Current of past history of congestive heart failure
• Current or past history of peripheral artery disease
• Current or past history of liver disease
• Current or past history of kidney disease
• Uncontrolled diabetes mellitus (type I or II)
• Narrow-angle glaucoma
• Hypo- or hyper-thyroidism not adequately treated
• On medications (prescribed or OTC) known to affect appetite (e.g. diet pills), weight, or metabolism
• Current or past history (within the past 12 months) of major depression
• Current or past history (past 12 months) of alcohol or drug abuse or dependence
• Current or past history (lifetime) of amphetamine abuse or dependence
• Known history of learning disorder or developmental disability
• Current or past Attention Deficit Hyperactivity Disorder (ADHD)
• Pregnancy, planning to become pregnant, or lactation within the previous 6 months
• Waist circumference greater than 188cm
• Indwelling metallic object (e.g., pacemaker,pump), non-removable metal jewelry, medicinal patch or recent metallic ink tattoo
• Significant claustrophobia

Where it is running

• The New York State Psychiatric Institute at Columbia University Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

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