Adequacy of Perioperative Cefazolin for Surgery Antibiotic Prophylaxis in Obese Patients

Withdrawn before enrolling · Phase 4

Conditions studied: Obesity

In brief

The population continues to increase in weight. Currently there are no guidelines in the dosing of cefazolin for the obese population. Standard dosing of cefazolin 2 grams for patients \<120 kg and 3 grams for patients \>120 kg is used as the dose for surgical prophylaxis. This makes no provisions for weight based dosing. There has been some recent data which states this might not be enough for the obese patients. The primary objective of this study is to determine if weight based dosing (30 mg/kg) of cefazolin as surgical prophylaxis for patients undergoing elective gastric bypass/laparoscopic Roux-en-y gastric bypass provides appropriate serum concentrations for a larger percentage of time than the current method of giving the standard 2 or 3 gram doses of cefazolin peri-operatively. The concentration of cefazolin in tissue will also be measured to help assess this question.

Key facts

Study ID

NCT01886742

Run by

University of Colorado, Denver

People needed

0

Starts

2017-09-01

Expected to finish

2018-10-01

Last updated by the study team

2017-12-06

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• BMI greater than 40
• No known history of allergy to cephalosporins
• Scheduled for elective gastric bypass or laparoscopic Roux-en-y gastric bypass procedures
• Able to read and understand English

You may not qualify if…

• Patients <18 years of age or >89 Years of age
• Pregnant women, prisoners and decisionally challenged subjects will be excluded

Where it is running

• University of Colorado Hospital — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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