Proof of Concept Study of Gevokizumab in the Treatment of Pyoderma Gangrenosum

Completed · Phase 2

Conditions studied: Pyoderma Gangrenosum

In brief

The study will evaluate the safety and biologic activity of gevokizumab in subjects in the acute inflammatory phase of pyoderma gangrenosum.

Key facts

Study ID

NCT01882504

Run by

XOMA (US) LLC

People needed

8

Starts

2013-05-01

Expected to finish

2015-10-01

Last updated by the study team

2016-02-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• An established diagnosis of pyoderma gangrenosum
• Currently experiencing an inflammatory episode of pyoderma gangrenosum
• Contraceptive measures adequate to prevent pregnancy during the study

You may not qualify if…

• Clinical evidence of acutely infected pyoderma gangrenosum
• History of allergic or anaphylactic reactions to monoclonal antibodies
• History of recurrent or chronic systemic infections
• Female subjects who are pregnant, planning to become pregnant, have recently delivered, or are breast-feeding
• Other protocol-defined inclusion/exclusion criteria may apply

Where it is running

• Study site — Birmingham, Alabama, United States
• Study site — Miami, Florida, United States
• Study site — Miami Shores, Florida, United States
• Study site — Chicago, Illinois, United States
• Study site — Baltimore, Maryland, United States
• Study site — Ann Arbor, Michigan, United States
• Study site — Minneapolis, Minnesota, United States
• Study site — Verona, New Jersey, United States
• Study site — New York, New York, United States
• Study site — Winston-Salem, North Carolina, United States
• Study site — Cleveland, Ohio, United States
• Study site — Columbus, Ohio, United States
• Study site — Philadelphia, Pennsylvania, United States
• Study site — Knoxville, Tennessee, United States
• Study site — Arlington, Texas, United States
• Study site — Dallas, Texas, United States
• Study site — Houston, Texas, United States
• Study site — Salt Lake City, Utah, United States
• Study site — Norfolk, Virginia, United States

Full record on ClinicalTrials.gov

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