Tofacitinib In Psoriatic Arthritis Subjects With Inadequate Response to TNF Inhibitors

Completed · Phase 3 · Has a placebo group

Conditions studied: Psoriatic Arthritis

In brief

To examine the safety and efficacy of tofacitinib in subjects with active psoriatic arthritis who have previously had an inadequate response to at least one TNF inhibitor either due to lack of efficacy or an adverse event.

Key facts

Study ID

NCT01882439

Run by

Pfizer

People needed

395

Starts

2013-08-01

Expected to finish

2016-04-01

Last updated by the study team

2017-09-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Active arthritis at screening/baseline as indicated by >/= 3 tender/painful and 3 swollen joints
• Active plaque psoriasis at screening
• Inadequate efficacy or lack of toleration to previously administered TNF inhibitor

You may not qualify if…

• Non-plaque forms of psoriasis (with exception of nail psoriasis)
• History of autoimmune rheumatic disease other than PsA; also prior history of or current, rheumatic inflammatory disease other than PsA

Where it is running

• Rheumatology Associates of North Alabama, PC — Huntsville, Alabama, United States
• Arizona Arthritis & Rheumatology Associates, P.C. — Glendale, Arizona, United States
• Medvin Clinical Research — Covina, California, United States
• St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare — Fullerton, California, United States
• Ronald Reagan UCLA Medical Center, Drug Information Center — Los Angeles, California, United States
• UCLA David Geffen School of Medicine — Los Angeles, California, United States
• San Diego Arthritis Medical Clinic — San Diego, California, United States
• Stanford Hospital and Clinics — Stanford, California, United States
• New England Research Associates, LLC — Trumbull, Connecticut, United States
• Rheumatology Associates of Central Florida, PA — Orlando, Florida, United States
• Millennium Research — Ormond Beach, Florida, United States
• Arthritis Center, Inc. — Palm Harbor, Florida, United States
• Integral Rheumatology & Immunology Specialists (IRIS) — Plantation, Florida, United States
• Florida Medical Clinic, P.A. — Zephyrhills, Florida, United States
• St. Luke's Clinic - Rheumatology — Boise, Idaho, United States
• St. Luke's Intermountain Research Center — Boise, Idaho, United States
• Bluegrass Community Research, Inc — Lexington, Kentucky, United States
• Klein & Associates, M.D., P.A. — Hagerstown, Maryland, United States
• The Center For Rheumatology And Bone Research — Wheaton, Maryland, United States
• Brigham & Women's Hospital — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Clinical Pharmacology Study Group — Worcester, Massachusetts, United States
• St. Paul Rheumatology, PA — Eagan, Minnesota, United States
• Clayton Medical Research — St Louis, Missouri, United States
• Rheumatology Associates P.C. — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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