(-)-Epicatechin and Pulmonary Arterial Hypertension
Withdrawn before enrolling · Phase 1
Conditions studied: Pulmonary Arterial Hypertension
In brief
Pulmonary arterial hypertension (PAH) is a progressive disease that results in severe activity limitation and death. There are few treatments for PAH and the available medications are expensive, difficult to administer and have significant toxicities. (-)-Epicatechin is a non-toxic compound that naturally occurs in foods such as tea, wine and chocolate. Clinical intervention studies using dark chocolate in normal volunteers and subjects at risk for or with established cardiovascular disease have demonstrated improvements in peripheral and coronary vascular endothelial function, blood pressure, lipids, glucose tolerance and inflammatory markers. Our study intends to examine the hemodynamics effects of purified (-)-epicatechin in subjects with pulmonary arterial hypertension. We hypothesize purified (-)-epicatechin will reduce pulmonary vascular resistance in patients with pulmonary arterial hypertension.
Key facts
- Study ID
- NCT01880866
- Run by
- University of California, San Francisco
- People needed
- 0
- Starts
- 2013-07-01
- Expected to finish
- 2014-01-01
- Last updated by the study team
- 2014-09-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female age 18 or older
- NYHA Class II-!V
- 6 minute walk distance < 450 meters
- Outpatients with suspected WHO group I PAH or and established diagnosis of WHO group I PAH undergoing clinically indicated right heart catheterization
- Written informed consent obtained from subject and ability for subject to comply with the requirements of study
You may not qualify if…
- Pregnancy
- Breast feeding
- Systolic blood pressure <100 or >160
- History of migraine headaches
- Allergy or intolerance to chocolate, tea or wine
- Subject is considered unsuitable for the study in the opinion of the investigator, nurse practitioner, or study physician for any other reason
Where it is running
- UCSF — San Francisco, California, United States
Full record on ClinicalTrials.gov
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