Molecular Phenotyping of Asthma in Sickle Cell Disease
Completed
Conditions studied: Sickle Cell Disease, Asthma
In brief
Asthma and sickle cell disease each are serious medical problems. People with asthma have difficulty breathing, wheeze (a whistling noise when breathing), cough, produce sputum or phlegm, and have inflammation (swelling, irritation, redness) and narrowing of the bronchial tubes. When a person has both asthma and sickle cell disease together, more serious medical problems can occur such as having acute chest syndrome and pain episodes more often. It is sometimes hard to diagnose asthma in a person with sickle cell disease because sickle cell disease can also cause lung problems. The purpose of this study is to see if the investigators can better understand asthma when it occurs in a person who has sickle cell disease. The investigators will do this by taking a blood, urine, and saliva sample. The blood and urine samples will be analyzed for chemicals and DNA (genes). Certain genes can cause patients to have sickle cell disease or asthma. The investigators will use the saliva sample for future studies to compare the results from the blood testing with saliva. The investigator's long-term goal is to make sure people who have asthma and sickle cell disease are getting the best asthma treatments. The investigator's hypothesis is that the analysis of the blood, urine and saliva using a method called, metabolomics, may identify a unique asthma signature in children with sickle cell disease which may lead to targeted treatments.
Key facts
- Study ID
- NCT01879592
- Run by
- Nemours Children's Clinic
- People needed
- 99
- Starts
- 2011-06-01
- Expected to finish
- 2016-02-28
- Last updated by the study team
- 2017-03-28
Who can join
Age: 6 and older, up to 20. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients are aged 6 years old up to 21 years old
- Children with sickle cell disease with the genotype SS, SC, or S β 0 thal
- African American children with asthma who do not have sickle cell disease or sickle cell disease trait.
- African American children with no chronic disease
- Physician diagnosed asthma and atopy (of any asthma severity) plus a family history of asthma 89,90
- Patients whose controller respiratory medications and maintenance medications for sickle cell disease (e.g. hydroxyurea) have been unchanged for the previous 4 weeks
You may not qualify if…
- Patients who are current smokers
- Patients who had an inflammatory event related to sickle cell disease (pain episode, priapism, acute chest syndrome, urgent medical visit), asthma exacerbation, or respiratory infection within 1 month prior to the blood, saliva, and urine collection.
- Patients who are receiving chronic transfusion therapy and who have received a transfusion within 90 days prior to blood, saliva, and urine collection.
- Patients who have received treatment with a leukotriene synthesis inhibitor or a leukotriene modifier[montelukast (Singulair®)] within the 2 weeks prior to blood and urine collection.
- Women who are pregnant or lactating
Where it is running
- Nemours Children's Clinic — Wilmington, Delaware, United States
- Nemours Children's Clinic — Jacksonville, Florida, United States
- Nemours Children's Clinic — Orlando, Florida, United States
Full record on ClinicalTrials.gov
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