Endothelial Function in Obese Adolescents
Completed · Not applicable
Conditions studied: Insulin Resistance, Glucose Intolerance, Obesity, Atherosclerosis
In brief
Childhood obesity is perhaps the most significant public health problem in the most developed countries and is rapidly becoming so in developing countries. National Health and Nutrition Examination Survey data shows a 3-fold increase in the prevalence of obesity in childhood, over past few decades. Furthermore, childhood obesity has markedly contributed to the prevalence of the metabolic syndrome and type 2 diabetes in U.S. children. Alarmingly, there is increasing evidence that atherosclerosis develops silently during childhood in obese children. In the Bogalusa Heart Study, pediatric autopsy studies showed a clear relationship between the number and severity of risk factors, principally obesity, with atherosclerosis in both the aorta and coronary arteries. Increased intimal medial thickness (IMT) was not present among obese adults who had been normal weight as children, emphasizing the cumulative effects of childhood obesity persisting into adulthood. Thus, the need for primary prevention of cardiovascular disease beginning in childhood is strongly suggested.
Key facts
- Study ID
- NCT01879033
- Run by
- Montefiore Medical Center
- People needed
- 60
- Starts
- 2011-03-01
- Expected to finish
- 2014-01-01
- Last updated by the study team
- 2019-01-22
Who can join
Age: 12 and older, up to 18. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Children in the age range of 12-18 years
- For the lean group, age and sex matched subjects with BMI between 5th-85th percentiles
- Obese group defined as BMI ≥95th percentile. These will further be subgrouped into those with normal and those with abnormal glucose tolerance normal glucose tolerance (NGT) defined as fasting glucose level<100mg/dl and a 2 hour postprandial glucose level<140mg/d and abnormal OGTT defined as fasting level ≥100mg/dl and/or 2hr ≥140 using a glucose load of 1.75 g/kg body weight (max 75 g).Hence, we will
Where it is running
- Albert Einstein College of Medicine West Campus Clinical Research Center — The Bronx, New York, United States
Full record on ClinicalTrials.gov
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