PVI Using Cryoablation Alone in Paroxysmal AF Patients Converted From Persistent AF With Dofetilide
Withdrawn before enrolling
Conditions studied: Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
In brief
To determine the efficacy of cryoablation alone in patients with paroxysmal atrial fibrillation who have been pretreated with dofetilide and converted from persistent atrial fibrillation.
Key facts
- Study ID
- NCT01877486
- Run by
- University of Rochester
- People needed
- 0
- Starts
- 2016-01-01
- Expected to finish
- 2016-12-01
- Last updated by the study team
- 2016-10-04
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Aged 18 to 80 years
- Able and willing to give written informed consent
- Paroxysmal AF, defined as recurrent AF ( ≥ 2 episodes in 1 month) that terminates within 7 days as assessed by ECG recordings
- Prior persistent AF, defined as sustained beyond seven days and up to one year, successfully converted to paroxysmal AF by dofetilide
You may not qualify if…
- Previous ablation for AF
- Left atrial size larger than 60mm (parasternal view on transthoracic echocardiogram)
- Patients who have AF episodes triggered by another uniform arrhythmia (e.g. atrial flutter or atrial tachycardia)
- Presence of severe valvular disease with the need for surgical correction
- AF deemed secondary to a transient or correctable abnormality including electrolyte imbalance, trauma, recent surgery, infection, toxic ingestion, and endocrinopathy
- Pregnant women or women of child bearing potential and not on reliable methods of birth control
- Second or third degree AV block, sinus pause > 3 seconds, resting heart rate< 30 bpm without permanent pacemaker
- History of drug-induced Torsades de Pointes or congenital long QT syndrome
- Uninterrupted AF for more than 12 months prior to randomization unless sinus rhythm maintained for ≥ 24 hours after cardioversion.
Where it is running
- Valley Hospital — Ridgewood, New Jersey, United States
Full record on ClinicalTrials.gov
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