Effects of SQ109 on QTc Interval in Healthy Subjects

Withdrawn before enrolling · Phase 1 · Has a placebo group

Conditions studied: Tuberculosis

In brief

This will be a single center, open label, crossover study to evaluate the safety and tolerability of multiple dose levels of SQ109.

Key facts

Study ID

NCT01874314

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

0

Expected to finish

2015-12-01

Last updated by the study team

2014-03-24

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women aged 18 to 45 years, inclusive.
• Ability to understand the consent process and procedures.
• Informed consent obtained and signed.
• Comprehension of the study objectives and procedures which will be determined by the recruiter using a series of questions after explaining the procedures.
• Subject agrees to be available for all study visits and is able to comply with protocol requirements for the entire duration of the study.
• Subject agrees not to participate in another clinical trial at any time during the study period.
• Subjects who have a body mass index (BMI) >/=18 kg/m\^2 and </= 35 kg/m\^2
• General good health, without current medical illness or clinically significant abnormal physical examination findings that classify the subject as other than healthy as determined by study investigators
• Negative serum pregnancy test at screening and a negative urine pregnancy test on the day of admittance to the inpatient phase for all female subjects of child bearing potential.
• Negative urine toxicity screen for alcohol, marijuana, cocaine metabolite, amphetamines, opiates, PCP, barbiturates, and benzodiazepines.
• Agreement by subjects with reproductive potential to use an adequate method of contraception during the study and for 90 days after study drug administration. Female subjects must agree to the use of two reliable methods of contraception while receiving study drug and for 90 days after study drug administration, which can include: condoms, spermicidal gel, diaphragm, hormonal or non-hormonal intrauterine device, surgical sterilization, oral contraceptive pill, and depot progesterone injections. If a male subject is heterosexually active, the subject and his partner must use at least two forms of the listed contraceptive methods.

You may not qualify if…

• Subjects meeting any exclusion criteria at baseline will be excluded from study partcipation.
• Note that individuals with a history of cardiac arrhythmias will not be included as subjects in this study.
• Medical condition that precludes participation, including the following:
• Hypertension with confirmed systolic blood pressure >140 mmHg or confirmed diastolic blood pressure >90 mmHg, measured after 10 - 15 minutes of rest.
• Morbid obesity (BMI>35)
• Current diagnosis of pulmonary disease including latent TB
• Current diagnosis of asthma, which has required use of asthma medications within the past year
• History of or current diagnosis of diabetes
• Autoimmune disorder, such as lupus, Wegener's, rheumatoid arthritis
• History of malignancy except low-grade skin cancer, (i.e., basal cell carcinoma thought to be cured)
• Chronic renal, hepatic, or pulmonary disease condition that could interfere with the absorption of the study drug (e.g., surgical resection of significant proportions of the stomach or bowel, gastric bypass, gastric banding, irritable bowel syndrome, inflammatory bowel disease)
• History of known Clostridium difficile infection
• Blood donation within the previous 6 weeks
• History of cardiac rhythm abnormality including Wolff/Parkinson/White syndrome
• History of prolonged QT interval
• History of allergy or photosensitivity to fluoroquinolones
• Prolongation of QTcF interval (i.e., confirmed QTcF interval of 450 milliseconds or greater)
• Clinically significant abnormal 12 lead electrocardiogram at screening in the judgment of the investigator, or based on the formal ECG reading; history of any cardiac abnormalities, including conduction abnormalities such as Wolff-Parkinson-White, dysrhythmias, or coronary artery disease
• Laboratory abnormalities at Screening outside of the ranges given below. Note, if one or more screening laboratory values are outside the acceptable range on the initial screen, the abnormal test(s) may be repeated once from a single blood draw:
• Serum creatinine (<1.1 x ULN),
• Hemoglobin (11.0-17.5g/dL),
• Platelet count (125,000-450,000mm\^3),
• Absolute neutrophil count (>1300 mm\^3),
• Aspartate aminotransferase (AST, </=1.2 x ULN),
• Alanine aminotransferase (ALT, </=1.2 x ULN),

Where it is running

• Case Western Reserve University - Case Medical Center - Infectious Disease & HIV Medicine — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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