Study of Brentuximab Vedotin Combined With Bendamustine in Patients With Hodgkin Lymphoma

Completed · Phase 1/Phase 2

Conditions studied: Hodgkin Disease

In brief

The purpose of this study is to assess safety and efficacy of brentuximab vedotin in combination with bendamustine in patients with relapsed or refractory Hodgkin lymphoma. It is an open-label, 2-stage study designed to determine the recommended dose level of bendamustine in combination with brentuximab vedotin. The study will assess the safety profile of the combination treatment and determine what proportion of patients achieve a complete remission.

Key facts

Study ID

NCT01874054

Run by

Seagen Inc.

People needed

55

Starts

2013-06-01

Expected to finish

2018-02-20

Last updated by the study team

2019-02-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histopathological diagnosis of classical Hodgkin lymphoma
• Failed standard front-line therapy
• Measurable disease of at least 1.5 cm as documented by radiographic technique
• Eastern Cooperative Oncology Group performance status less than or equal to 2

You may not qualify if…

• Received prior salvage therapy, including radiotherapy
• Chemotherapy, radiotherapy, biologics, and/or other treatment with immunotherapy not completed 4 weeks prior to first dose of study drug
• Concurrent use of other investigational agents

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• Pacific Hematology Oncology Associates — San Francisco, California, United States
• Stanford Cancer Center — Stanford, California, United States
• Oncology Institute of Hope & Innovation, The — Whittier, California, United States
• Colorado Blood Cancer Institute — Denver, Colorado, United States
• Dana Farber Cancer Institute — Boston, Massachusetts, United States
• Mayo Clinic Minnesota — Rochester, Minnesota, United States
• University of Nebraska Medical Center — Omaha, Nebraska, United States
• Columbia University Medical Center — New York, New York, United States
• Jewish Hospital, The — Cincinnati, Ohio, United States
• Case Western Reserve University / University Hospitals Case Medical Center — Cleveland, Ohio, United States
• Saint Francis Hospital / Bon Secours — Greenville, South Carolina, United States
• Charles A. Sammons Cancer Center / Baylor University Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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