Effect of 10-day Overnight Hypoxia Treatment on Whole Body Insulin Sensitivity (SLEEP HIGH Study)

Completed · Early Phase 1

Conditions studied: Insulin Resistance

In brief

The purpose of this study is to look at how a reduction in oxygen levels (hypoxia) influences insulin sensitivity and carbohydrate metabolism. It is expected that 10 nights of exposure to moderate hypoxia (\~ 15% O2, similar to conditions at an altitude of \~7500 feet) will improve glucose metabolism.

Key facts

Study ID

NCT01872533

Run by

Pennington Biomedical Research Center

People needed

9

Starts

2011-07-01

Expected to finish

2013-05-01

Last updated by the study team

2015-12-02

Who can join

Age: 20 and older, up to 45. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Aged 20-45 years
• Male
• Obese category (BMI > 30 kg/m2)
• Healthy as assessed by a self-reported health questionnaire
• Non-smokers
• Weight stable over the past 3 months (<2kg fluctuation)

You may not qualify if…

• Female
• Diabetes
• Sleep apnea
• Hypertension
• History of altitude sickness
• Individuals taking any chronic medications
• Individuals taking any stimulants
• Individuals taking beta-blockers
• Individuals with chronic alcohol consumption (>3 drinks per day) or drug abuse.
• Individuals unable to abstain from caffeinated beverage or alcohol the days of study testing
• Individuals with history disease or history of stroke

Where it is running

• Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States

Full record on ClinicalTrials.gov

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