7% Hypertonic Saline for Acute Bronchiolitis

Completed · Phase 4

Conditions studied: Acute Bronchiolitis

In brief

Research suggests that hypertonic saline may improve mucous flow in infants with acute bronchiolitis. Data suggest a trend favoring reduced length of hospital stay and improved pulmonary scores with increasing concentration of nebulized solution to 3% and 5% saline as compared to 0.9% saline mixed with epinephrine. To our knowledge, 7% hypertonic saline has not been previously investigated. OUr hypothesis was that 7% hypertonic saline would improve bronchiolitis severity scores and admission rate.

Key facts

Study ID

NCT01871857

Run by

Le Bonheur Children's Hospital

People needed

101

Starts

2010-11-01

Expected to finish

2012-08-01

Last updated by the study team

2013-06-11

Who can join

Age: 0 and older, up to 2. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients age 6 weeks to ≤ 18 months
• Diagnosed with bronchiolitis (defined as viral respiratory illness and first episode of wheeze)
• BSS score of ≥ 4

You may not qualify if…

• A previous history of wheezing;
• diagnosis of asthma;
• any use of bronchodilators within 2 h of presentation
• gestational age ≤ 34 weeks
• history of congenital heart disease
• chronic pulmonary or chronic renal disease
• oxygen saturation of ≤ 85% at the time of recruitment
• severe disease requiring intensive care unit admission
• inability to obtain informed consent

Where it is running

• Le Bonheur Children's Hospital — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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