Ovarian Tissue Transplantation
Recruiting now · Not applicable
Conditions studied: Infertile Females or Females With Ovarian Insufficiency
In brief
Chemotherapy and radiation therapy for the treatment of cancer can compromise fertility. Ovarian tissue cryopreservation is an experimental strategy offered at The University of Pennsylvania to preserve future fertility (protocol 806062). The primary objective of this study is to determine the efficacy and safety of autologous transplantation of previously cryopreserved ovarian cortical tissue in patients who experience infertility or ovarian insufficiency after cancer treatments.
Key facts
- Study ID
- NCT01870752
- Run by
- Abramson Cancer Center at Penn Medicine
- People needed
- 10
- Starts
- 2013-06-01
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2025-09-10
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Female patient between the ages of 18 and 45 years
- Previously cryopreserved and stored cortical ovarian tissue available for autologous transplantation
- Ovarian insufficiency defined as an elevated FSH over 10
- Inability to conceive after 6 months of unprotected intercourse with male
- Reasonably good health
- Candidate for pregnancy
- Written clearance for the procedure from the patients oncologist
You may not qualify if…
- Patients considered to be high risk for surgical complications will be excluded from the research protocol
- Women who are known to be positive for the BRCA mutation
- Women with a history of leukemia, ovarian cancer or a cancer that likely involved the ovaries at the time of ovarian tissue collection
- Women with psychological, psychiatric, or other conditions which prevent giving fully informed consent
- Current pregnancy
Where it is running
- Abramson Cancer Center of the University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
Full record on ClinicalTrials.gov
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