Differential Effects of Various Anesthetic Agents on Cognitive Function in Patients With Alzheimer's Disease

Withdrawn before enrolling

Conditions studied: Alzheimer Disease

In brief

The objective of the study is to determine the effects of different anesthetic agents on cognitive function in patients with Alzheimer's disease (AD). The investigators will test the hypothesis that anesthesia with desflurane or propofol, compared to isoflurane or sevoflurane, will have less of an effect on post-operative cognitive dysfunction in patients with AD.

Key facts

Study ID

NCT01870453

Run by

Massachusetts General Hospital

People needed

0

Starts

2013-10-01

Expected to finish

2018-12-01

Last updated by the study team

2018-08-16

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients diagnosed with Alzheimer's disease (AD) per Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria.
• Patient recruitment permission granted by his/her surgeon
• Requires general anesthesia for elective noncardiac, nonneurologic, nonvascular surgery.

You may not qualify if…

• History of neurologic or psychiatric disease (i.e. stroke, psychosis, etc.)
• Non-native English speaker
• Severe visual or auditory disorder
• Sensitivity to sulfites (some propofol formulations at MGH may contain sodium metasulfite).
• Asthma (sulfite sensitivity is seen more frequently in asthmatic than in non-asthmatic people).

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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