PEACE: Pediatric Antifungal Comparative Effectiveness

Completed

Conditions studied: Pediatric Invasive Candidiasis

In brief

The overarching objective is to develop new evidence-based treatment guidelines for invasive fungal diseases in children. To accomplish that, this protocol will focus on two specific aims: 1) Compare the effectiveness of echinocandin versus amphotericin B or triazole antifungal therapy for pediatric invasive candidiasis and for the subset of patients with invasive candidemia; 2) Characterize the incidence rate of inpatient pediatric invasive candidiasis per hospital admissions.

Key facts

Study ID

NCT01869829

Run by

Duke University

People needed

750

Starts

2015-01-01

Expected to finish

2018-04-01

Last updated by the study team

2022-01-28

Who can join

Age: 0 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females age > 120 days and <18 years
• Documented proven or probable case of invasive candidiasis
• Parental/guardian permission (informed consent, if required) and if appropriate, child assent (if required).

You may not qualify if…

• Any history of prior Candida infection within the previous 35 days (These patients will not be eligible for analysis in aim 1 but will be eligible for inclusion of aim 2)

Where it is running

• Arkansas Children's Hospital — Little Rock, Arkansas, United States
• Children's Hospital of Orange County — Orange, California, United States
• Lucile Packard Children's Hospital at Stanford — Palo Alto, California, United States
• Rady Children's Hospital — San Diego, California, United States
• UCSF Benioff Children's Hospital — San Francisco, California, United States
• Children's Hospital Colorado — Aurora, Colorado, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• All Children's Hospital — St. Petersburg, Florida, United States
• Ann and Robert Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
• Boston Children's Hospital — Boston, Massachusetts, United States
• Mott Children's Hospital — Ann Arbor, Michigan, United States
• Children's Hospital and Clinics of Minnesota — Minneapolis, Minnesota, United States
• Children's Mercy — Kansas City, Missouri, United States
• Cohen Children's Medical Center of New York — New Hyde Park, New York, United States
• New York Presbyterian Phyllis and David Komansky Center for Children's Health — New York, New York, United States
• Duke University — Durham, North Carolina, United States
• Cincinnati Children's Medical Center — Cincinnati, Ohio, United States
• Cleveland Clinic Children's — Cleveland, Ohio, United States
• OHSU Doernbecher Children's Hospital — Portland, Oregon, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States
• St. Jude Children's Research Hospital — Memphis, Tennessee, United States
• Monroe Carell Jr. Children's Hospital at Vanderbilt — Nashville, Tennessee, United States
• Dell Children's Medical Center — Austin, Texas, United States
• Texas Children's Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

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