Effect of Buffered Numbing Solution on Patients With Toothaches

Completed · Not applicable

Conditions studied: Irreversible Pulpitis (Toothache)

In brief

The purpose of this study is to determine the effect of buffered lidocaine (a numbing solution) on the ability to numb patients with toothaches. Buffered anesthetic (numbing) solutions have shown promise in some medical and dental research. Patients presenting with toothaches will be given either a buffered numbing solution or a nonbuffered numbing solution. Neither the patient nor the operator will know which solution they will receive. Root canal treatment will be performed on the tooth and the ability of the buffered versus non-buffered numbing solutions will be compared.

Key facts

Study ID

NCT01868776

Run by

Ohio State University

People needed

100

Starts

2013-03-01

Expected to finish

2013-12-01

Last updated by the study team

2020-10-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients with a diagnosis of irreversible pulpitis (toothache) in a mandibular posterior tooth (back/bottom tooth) with moderate to severe pain
• ages 18 -65 years of age
• in good health (ASA I or II)
• able to grant informed consent.

You may not qualify if…

• allergy to lidocaine (numbing solution
• significant medical problem (ASA III or IV)
• have taken CNS depressants or analgesic medications within the last 24 hours
• pregnancy or lactating
• non-English speaking
• inability to give informed consent

Where it is running

• The Ohio State University College of Dentistry, Postle Hall — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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