Testing the Anesthetic Effectiveness of Buffered Articaine Injected Next to a Lower First Molar.
Completed · Phase 4
Conditions studied: Anesthetic Effectiveness
In brief
Infiltration (injecting next to the tooth) injections are common in dentistry and a number of studies have shown that articaine anesthetic, when injected next to a lower molar, is more effective than a local anesthetic injection of lidocaine. However success rates have not been as high as hoped for. No objective study has addressed the success rate of buffering articaine in a mandibular primary buccal infiltration of the first molar. Therefore, the purpose of this prospective, randomized, double-blind, crossover study is to compare the degree of pulpal anesthesia obtained with a buffered 4% articaine with 1:100,000 epinephrine solution versus a non-buffered 4% articaine with 1:100,000 epinephrine solution as a primary infiltration in the mandibular first molar. The investigators will also record the pain of injection and postoperative pain.
Key facts
- Study ID
- NCT01862614
- Run by
- Ohio State University
- People needed
- 80
- Starts
- 2013-04-01
- Expected to finish
- 2014-05-01
- Last updated by the study team
- 2021-05-26
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Between the age of 18-65 years.
- in good health (ASA classification II or higher).
- able to provide informed consent.
You may not qualify if…
- allergy to articaine.
- history of significant medical problems (ASA classification of III or worse).
- diagnosed depression (taking tri-cyclic antidepressant medications to control).
- have taken central nervous system (CNS) depressants (including alcohol or any analgesic medications) within the last 48 hours prior to testing.
- lactating or pregnant.
- inability to give informed consent.
Where it is running
- The Ohio State University College of Dentistry, Postle Hall — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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