Valproic Acid in Childhood Progressive Brain Tumors

Withdrawn before enrolling · Phase 1

Conditions studied: Pediatric Brain Tumor, Glioma, Anaplastic Astrocytoma, Medulloblastoma, Glioblastoma

In brief

The study investigates valproic acid added to radiation and temozolomide therapy (standard of care) for progressive or recurrent pediatric brain tumors.

Key facts

Study ID

NCT01861990

Run by

Medical University of South Carolina

People needed

0

Starts

2013-05-01

Expected to finish

2013-12-01

Last updated by the study team

2015-05-22

Who can join

Age: 1 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject, parent, or guardian willing and able to give informed consent
• Recurrent or progressive pediatric brain tumor, with MRI evidence of disease
• Age at first diagnosis of brain tumor 1-21 years old
• Lansky or Karnofsky performance score of at least 50 at diagnosis

You may not qualify if…

• Pregnancy
• Prior intolerance to valproic acid
• History of use of temozolomide
• Use of enzyme inducing anticonvulsant medications (see appendix B)
• Known urea cycle disorder (e.g. ornithine transcarbamylase deficiency)

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.