The Effects of Buprenorphine on Responses to Verbal Tasks

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Basic Science

In brief

In this study, the investigators will examine the effects of buprenorphine, as compared to placebo, upon physiological, subjective, and hormonal responses to a stressful speech task and a non-stressful control task in healthy adults. There is strong evidence in support of the role of endogenous opioids and opiates in mediating social behavior in humans and other animals, and particularly, in social distress. Recently it has been shown that buprenorphine, a partial mu-opioid agonist, reduces sensitivity to recognition of fearful facial expressions in humans. Here, the investigators propose to further explore the role of the opioid system in mediating stress responses in humans through the use of buprenorphine. The investigators hypothesize that buprenorphine with reduce both physiological and subjective measures of stress.

Key facts

Study ID

NCT01860287

Run by

University of Chicago

People needed

48

Starts

2013-09-01

Expected to finish

2017-01-01

Last updated by the study team

2019-08-01

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy men and women
• ages 18-40 years
• high school education
• fluent in English

You may not qualify if…

• history of adverse drug reactions
• taking oral contraceptives or planning to become pregnant
• taking any medications
• smokers
• night shift workers
• drink more than 4 alcoholic or caffeinated drinks per day

Where it is running

• University of Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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