Intestinal Bacteria and Ocular Inflammatory Disease

Completed

Conditions studied: Uveitis

In brief

Background: \- Uveitis is a general term describing a group of inflammatory diseases of the eye. The causes of uveitis are not fully understood. Researchers want to look at bacteria in the body that might be related to the inflammation. They will study the natural bacteria present in the gut and intestines of people with and without uveitis to understand their potential role in these diseases. Objectives: \- To study the intestinal bacteria in people with and without uveitis or ocular inflammatory disease. Eligibility: * Individuals at least 18 years of age who have uveitis or ocular inflammatory disease. * Individuals at least 18 years of age without uveitis or ocular inflammatory disease to serve as healthy controls. Design: * Participants may have more than one study visit (approximately 2-4) to assess possible changes in microbiome composition associated with treatment or disease activity. * At each visit, participants will have a full eye examination, including vision and eye pressure tests. They will provide blood samples for testing. Participants will also be provided a stool collection kit to take home. The samples may be sent or brought back to the clinic. * Treatment will not be provided as part of this study.

Key facts

Study ID

NCT01859299

Run by

National Eye Institute (NEI)

People needed

131

Starts

2013-08-27

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Exclusion Criteria for Uveitis Participants
• Participants who are unable to provide informed consent.
• Recent (<3 months prior) use of any antibiotic therapy
• Current consumption of probiotics
• Current extreme diet (parenteral nutrition, macrobiotic diet, etc.)
• Known gastrointestinal (GI) tract neoplasm
• Recent GI tract infection (gastroenteritis, colitis, diverticulitis, appendicitis) within the last month
• Chronic unexplained diarrhea
• Participant has or had a significant active infection (an infection requiring treatment as determined by the investigator) that required systemic antibiotic treatment within the past three months
• Participant has any GI tract surgery leaving permanent residua (e.g., gastrectomy; bariatric surgery; colectomy)
• Participant has inflammatory bowel disease (IBD)
• Participant is pregnant or lactating.
• Exclusion Criteria for Healthy Volunteers
• Recent (<3 months prior) use of any antibiotic therapy
• Current consumption of probiotics
• Current extreme diet (parenteral nutrition, macrobiotic diet, etc.)
• Known gastrointestinal (GI) tract neoplasm
• Recent GI tract infection (gastroenteritis, colitis, diverticulitis, appendicitis) within the last month
• Chronic unexplained diarrhea
• Participant has or had a significant active infection (an infection requiring treatment as determined by the investigator) that required systemic antibiotic treatment within the past three months
• Participant has any GI tract surgery leaving permanent residua (e.g., gastrectomy; bariatric surgery; colectomy)
• Participant has inflammatory bowel disease (IBD)
• Participant is pregnant or lactating.

Where it is running

• National Institutes of Health Clinical Center — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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