Using Continuous Positive Airway Pressure to Reduce the Incidence of Acute Kidney Injury in Hospitalized Patients With Chronic Kidney Disease
Withdrawn before enrolling · Not applicable
Conditions studied: Chronic Kidney Disease, Obstructive Sleep Apnea
In brief
Obstructive sleep apnea (OSA) is a common and undertreated condition in patients with chronic kidney disease (CKD). Both physiologic and empiric data suggest that renal hypoxia due to OSA is associated with worsening kidney function. Hospitalized patients are often exposed to multiple nephrotoxins such as antibiotics, contrast agents, and diuretics, which place them at risk for acute worsening of kidney function. This study aims to determine whether immediate diagnosis and treatment of OSA in CKD patients will decrease the incidence of acute kidney injury during hospitalization. The investigators will evaluate the extent to which this effect can be attributed to a decrease in nocturnal hypoxia and improved blood pressure control. Secondary endpoints include hospital length of stay, and a composite outcome comprised of hemodialysis initiation, major cardiovascular events, and mortality.
Key facts
- Study ID
- NCT01859260
- Run by
- University of South Florida
- People needed
- 0
- Starts
- 2013-05-30
- Expected to finish
- 2014-07-01
- Last updated by the study team
- 2019-04-29
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- CKD defined by National Kidney Foundation Staging system: eGFR < 60
- Overnight sleep study consistent with OSA
You may not qualify if…
- Currently treated with positive airway pressure for sleep-disordered breathing
- Hemodynamically unstable, defined as SBP < 90, or use of vasopressors
- Intubated or mechanically ventilated
- Respiratory insufficiency, defined as P/F ratio < 250, or requiring mechanical ventilation
- End stage renal disease on renal replacement therapy
- Contraindication to CPAP, including active emesis, recent intracranial surgery, altered level of consciousness
Where it is running
- Tampa general hospital — Tampa, Florida, United States
Full record on ClinicalTrials.gov
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