Green Tea Confections For Managing Postprandial Hyperglycemia-Induced Vascular Endothelial Dysfunction

Completed · Not applicable

Conditions studied: Hyperglycemia, Cardiovascular Disease

In brief

The objective of this study is to formulate and validate a green tea confection (i.e. "gummy" candy) as a strategy to attenuate postprandial hyperglycemia-induced impairments in vascular function. The central hypothesis is that a green tea confection will protect against vascular endothelial dysfunction by suppressing postprandial hyperglycemia. The central hypothesis of this application will be assessed by developing a green tea-containing confection, examining its physiochemical properties and its inhibition of starch digestion, and then validating its vasoprotective activities in healthy humans by assessing its blood glucose-regulating activities.

Key facts

Study ID

NCT01857258

Run by

Ohio State University

People needed

15

Starts

2013-05-01

Expected to finish

2016-04-01

Last updated by the study team

2017-02-16

Who can join

Age: 18 and older, up to 30. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Plasma glucose <100 mg/dL
• Plasma total cholesterol <200 mg/dL
• Plasma triglycerides <140 mg/dL
• Blood pressure <140/90
• non-dietary supplement user for >2 months
• no use of medications known to affect carbohydrate metabolism,
• nonsmoker / never smoker
• no history of cardiovascular disease or gastrointestinal disorders

You may not qualify if…

• allergies or aversions to green tea and/or corn starch,
• excessive alcohol consumption (>3 drinks/d),
• >5 h/wk of aerobic activity

Where it is running

• The Ohio State University — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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