Effect of Vitamin D Supplementation on Oral Glucose Tolerance Among Obese Adolescents
Completed · Not applicable
Conditions studied: Insulin Resistance
In brief
Childhood obesity is a rapidly growing epidemic in the US and the world. Current estimates suggest that 30% of our nation's children are either overweight ot obese. Obesity is a major risk factor towards the development of insulin resistance, which, in turn is a major risk factor for the development of type 2 diabetes. Prior research has suggested that vitamin D therapy may be a safe, inexpensive, and effective method of reducing insulin resistance and a person's risk of developing diabetes. The investigators' prior studies have shown that daily 4,000 IU vitamin D therapy is a safe and effective method of improving insulin resistance based on a calculation called the HOMA-IR. The next step in identifying whether vitamin D truly improves insulin resistance is to use oral glucose tolerance testing (OGTT), which is a better real-life measure of insulin resistance compared to the previously used HOMA-IR.
Key facts
- Study ID
- NCT01856946
- Run by
- University of Missouri-Columbia
- People needed
- 15
- Starts
- 2013-05-01
- Expected to finish
- 2014-02-01
- Last updated by the study team
- 2016-10-10
Who can join
Age: 9 and older, up to 19. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Obese adolescent (BMI >85th percentile for age)
- 9-19 years of age
- attending the ADOBE clinic at the University of Missouri
- 25OH vitamin D level within past 3 months
You may not qualify if…
- use of vit D supplements other than standard multi-vitamin preparation (i.e., should not be receiving vit D > 1000 IU/d)
- use of medications that interfere with vit D metabolism (e.g., anti-convulsive)
- history of hepatic or renal disorders, hypercalciuria, or hypercalcemia
- undergoing UV radiation as medical therapy
- pregnancy; cigarette smoking; current use of a tanning bed
- current type 2 diabetes
- any current antihyperglycemic medication use (e.g. metformin, insulin) less than one month prior to initial OGTT.
Where it is running
- University of Missouri Adolescent Obesity Clinic — Columbia, Missouri, United States
Full record on ClinicalTrials.gov
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