Multiple Ascending Dose Study in Subjects With Type 2 Diabetes

Stopped early · Phase 1 · Has a placebo group

Conditions studied: Diabetes Mellitus

In brief

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics following ascending multiple doses of AMG 876 in subjects with type 2 diabetes.

Key facts

Study ID

NCT01856881

Run by

Amgen

People needed

86

Starts

2013-03-01

Expected to finish

2015-03-01

Last updated by the study team

2015-11-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female subjects ≥ 18 to ≤ 65 years of age at the time of randomization
• Female subjects must be of documented non-reproductive potential
• Diagnosed with type 2 diabetes
• HbA1c ≥ 6.5% and ≤ 10%
• Fasting C-peptide value ≥ 0.8 ng/mL
• Body mass index (BMI) between ≥ 25.0 and ≤ 40.0 kg/m2 at screening

You may not qualify if…

• Female subjects who are lactating/breastfeeding or who plan to breastfeed while on study through 4 weeks after receiving the last dose of study drug.
• Male subjects with partners who are pregnant or planning to become pregnant while the subject is on study through 4 weeks after receiving the last dose of study drug
• Evidence or history at screening of diabetic complications with significant end-organ damage, eg, proliferative retinopathy and/or macular edema, estimated glomerular filtration rate < 60 mL/min/1.73m2 (calculated using the Modification of Diet in Renal Disease formula) or macroalbuminuria (ie, ≥ +1 proteinuria on urinalysis), diabetic neuropathy complicated by neuropathic ulcers, or severe autonomic neuropathy with gastroparesis, chronic diarrhea, or hypoglycemic unawareness
• Significant cardiac disease, including but not limited to, evidence or history of coronary artery disease, unstable angina, congestive heart failure, known arrhythmias of atrial or ventricular etiology, unexplained syncope, or syncope/seizures related to arrhythmia
• Uncontrolled hypertension (systolic blood pressure ≥ 150 mmHg or diastolic blood pressure ≥ 90 mmHg) either on or off therapy at screening
• Triglycerides ≥ 500 mg/dL (5.64 mmol/L) at screening
• Hepatic liver enzymes ALT, AST, alkaline phosphatase (ALP), or total bilirubin (TBIL) levels > 1.5 times the upper limit of normal (ULN) at screening
• Fasting blood glucose > 270 mg/dL at the screening visit
• Positive for human immunodeficiency virus (HIV) antibodies, hepatitis B surface antigen (HbsAg), or hepatitis C virus antibodies (HepCAb)
• An unstable medical condition, defined as having been hospitalized within 28 days before day -1, major surgery within 6 months before day -1, or otherwise unstable in the judgment of the investigator (eg, risk of complications or adverse events unrelated to study participation)

Where it is running

• Research Site — Chula Vista, California, United States
• Research Site — Miramar, Florida, United States
• Research Site — Overland Park, Kansas, United States
• Research Site — Cincinnati, Ohio, United States
• Research Site — San Antonio, Texas, United States
• Research Site — Renton, Washington, United States

Full record on ClinicalTrials.gov

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