Effect of Liraglutide on Automated Closed-loop Glucose Control in Type 1 Diabetes

Completed · Early Phase 1

Conditions studied: Type 1 Diabetes

In brief

"Closed loop artificial pancreas" systems have been under development for the control of blood sugars in those living with diabetes. These systems consist of a continuous glucose sensor, which sends a signal to a computer program that automatically determines how much insulin to give. The computer program then tells an insulin pump to deliver the insulin. While such systems have been tested under a number of conditions, post-meal blood sugars are difficult to control. This study is designed to see if liraglutide, a glucagon like peptide receptor agonist, can help minimize the post meal blood sugar spikes in subjects with type 1 diabetes while they are on a closed loop system.

Key facts

Study ID

NCT01856790

Run by

Jennifer Sherr

People needed

15

Starts

2013-02-01

Expected to finish

2015-11-01

Last updated by the study team

2020-01-30

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age 18-40 years
• clinical diagnosis of Type 1 diabetes (T1D) (formal antibody and/or genetic testing will not be required)
• duration of T1D ≥ 1 year
• HbA1c ≤ 9 %
• Treated with CSII for at least 3 months
• Body weight > 50 kg (to accommodate phlebotomy)
• Be in good general health without other medical or psychiatric illnesses that would, in the judgment of the investigator, interfere with subject safety or study conduct

You may not qualify if…

• Insulin resistant (defined as requiring > 1.5 units/kg/day at time of study enrollment)
• Presence of any medical or psychiatric disorder that may interfere with subject safety or study conduct
• Use of any medications (besides insulin) known to blood glucose levels, including oral or other systemic glucocorticoid therapy. Inhaled, intranasal, or rectal corticosteroid use is allowed along as not given within 4 weeks of admission to the hospital research unit (HRU). Use of topical glucocorticoids is allowable as long as affected skin area does not overlap with study device sites. Subjects using herbal supplements will be excluded, due to the unknown effects of these supplements on glucose control
• History of hypoglycemic seizure within last 3 months
• Anemic (low hematocrit), evidence of renal insufficiency (elevated serum creatinine, BUN) or elevated liver function tests.
• Female subjects who are pregnant, lactating, or unwilling to be tested for pregnancy
• History of celiac disease gastroparesis, gastroesophageal reflux disease (GERD), disorder of gastric emptying, or disorder of intestinal motility
• Taking a medication known to affect gastric motility
• History of pancreatitis, gallstones, alcoholism or high triglyceride levels
• Personal or family history of thyroid cancer or multiple endocrine neoplasia type 2 (MEN2)
• Subjects unable to give consent

Where it is running

• Yale University School of Medicine — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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