Study of the Relationship Between Glycogen Storage Disease Type Ia and Inflammatory Bowel Disease

Completed

Conditions studied: Inflammatory Bowel Disease, Glycogen Storage Disease Type Ia

In brief

The purpose of this research study is to understand the relationship between inflammatory bowel disease (IBD) and Glycogen storage disease (GSD)type Ia. GSD type Ib has been established to have an association with IBD with clinical and histologic features that mirror those of Crohn disease. Development of the disease seems to be related to the defect of neutrophil function in individuals with GSD type Ib and subsequent colonic inflammation. In the last decade, it has become a standard for patients with GSD type Ib and gastrointestinal symptoms to be evaluated for IBD. Patients with GSD type Ia were not recognized to have similar gastrointestinal symptoms until recently. The prevalence of IBD is greater in patients with GSD type Ia versus the general population.

Key facts

Study ID

NCT01854242

Run by

University of Florida

People needed

50

Starts

2013-11-01

Expected to finish

2014-10-01

Last updated by the study team

2020-07-28

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Anyone with Glycogen Storage Disease type Ia

You may not qualify if…

• Anyone where the amount of blood needed to complete the Prometheus test exceeds 3ml/kg.

Where it is running

• University of Florida and Shands — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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