Exploration of Immune Response to Early PCV13 Vaccination in Conjunction With Autologous Transplant
Completed · Not applicable
Conditions studied: Multiple Myeloma
In brief
There is no study hypothesis. The purpose of this study is to see if the Pneumococcal conjugate vaccine (PCV13), when administered before and early after an autologous peripheral stem cell transplant will induce an immune response.
Key facts
- Study ID
- NCT01852591
- Run by
- H. Lee Moffitt Cancer Center and Research Institute
- People needed
- 8
- Starts
- 2013-02-01
- Expected to finish
- 2016-10-01
- Last updated by the study team
- 2017-02-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with confirmed multiple myeloma
- Eligible for treatment with high dose melphalan based regimen and autologous peripheral stem cell transplant
You may not qualify if…
- Pregnant or lactating woman, as evaluated by serum testing within 24 hours of administration of the first vaccine
- HIV infection confirmed by nucleic acid testing (NAT), as evaluated during pre transplant testing
- Common variable immunodeficiency or other inherited systemic immunodeficiency syndrome
- Active central nervous system (CNS) malignancy
- Prior malignancy within 5 years of enrollment excluding non-melanoma skin cancer or cervical carcinoma after curative resection, not requiring chemotherapy.
- History of severe allergy (e.g., anaphylaxis) to any component of pneumococcal conjugate vaccine 7 (PCV7), PCV13, or any diphtheria-toxoid containing vaccine.
- Inclusion on a separate trial in which patients may be randomized or otherwise started on maintenance chemotherapies within the first 3 months of autologous transplantation
- Patients with significant psychiatric illness likely to affect compliance, as determined by the treating physician
- Active or uncontrolled infection
- Diffusing lung capacity oxygenation (DLCO) <50 %
- Left ventricular ejection fraction (LVEF) <40%
- Bilirubin >2
Where it is running
- H.Lee Moffitt Cancer Center & Research Institute — Tampa, Florida, United States
Full record on ClinicalTrials.gov
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