Genetics of Insulin and Incretins in Cystic Fibrosis

Recruiting now

Conditions studied: Cystic Fibrosis

In brief

Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes. The mechanisms underlying CFRD development are not fully understood, but recent evidence suggests Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that augment insulin secretion in response to a nutrient load). This study will examine the prevalence of Genome wide association study (GWAS)-implicated T2DM alleles (including TCF7L2) across the spectrum of glucose abnormalities in CF and will use this information to compare incretin and insulin secretion in non-diabetic children and adults with high risk and low risk alleles.

Key facts

Study ID

NCT01852448

Run by

Children's Hospital of Philadelphia

People needed

550

Starts

2013-05-01

Expected to finish

2026-07-01

Last updated by the study team

2025-07-25

Who can join

Age: 2 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects age >2y
• Diagnosis of Cystic Fibrosis
• For subjects< 18 years, parental/guardian permission (informed consent) and if appropriate, child assent
• Exclusion Criteria 1. Established diagnosis of non-CFRD (cystic fibrosis related diabetes) (e.g T1DM)

Where it is running

• The Children's Hopsital of Philadelphia — Philadelphia, Pennsylvania, United States (enrolling)
• The University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.