Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs
Recruiting now
Conditions studied: Alpha-1 Antitrypsin Deficiency, AAT Deficiency, AATD, Cystic Fibrosis (CF)
In brief
The purpose of this study is to look at how Alpha-1-antitrypsin (AAT) deficiency and Cystic Fibrosis (CF) affect white blood cells in the lungs, called macrophages, and their ability to work.
Key facts
- Study ID
- NCT01851642
- Run by
- University of Florida
- People needed
- 220
- Starts
- 2007-08-09
- Expected to finish
- 2033-07-20
- Last updated by the study team
- 2025-11-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Signed informed consent
- Male or female 18 years of age or older
- Negative pregnancy test for women of childbearing potential
- Hemoglobin >12.5 g/dl measured on the day of participation
- Negative urine nicotine test
You may not qualify if…
- Pregnancy or breastfeeding
- Weight < 50 kg
- History of anemia requiring blood transfusions, erythropoietin supplementation, or iron supplementation within the past 36 months
- Known hemoglobin <12.5 g/dl within the past 90 days
- Systolic blood pressure > 180 mmHg and/or diastolic blood pressure >100 mmHg
- Poor venous access
- Large volume blood donation (>200 ml or 7 ounces) within the previous 56 days (e.g. blood donation for the purposes of blood banking)
- Clinically significant cardiac, hemostatic or neurological impairment or any other significant medical condition that, in the opinion of the investigator would affect subject safety (e.g., recent myocardial infarction, history of prolonged bleeding time, cerebral vascular accident, advanced cancer or uncontrolled medical condition)
- Psychiatric or cognitive disturbance or illness that would affect subject safety
- Current smoker
Where it is running
- Shands at the University of Florida — Gainesville, Florida, United States (enrolling)
Full record on ClinicalTrials.gov
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