Brain Mechanisms of Emotion and Motivation: A Mind-Body Study
Completed
Conditions studied: Stress, Anhedonia, Healthy
In brief
The purpose of this research study is to investigate how the brain processes emotions, and the way these processes affect behavior. Specifically, we hypothesize that individual differences in reward responsiveness will correlate with differential activation in mesolimbic regions of the brain and predict future wellbeing in follow-up interviews.
Key facts
- Study ID
- NCT01850472
- Run by
- Mclean Hospital
- People needed
- 88
- Starts
- 2013-03-01
- Expected to finish
- 2016-01-01
- Last updated by the study team
- 2018-05-22
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Absence of medical, neurological, and psychiatric illness (including alcohol and substance abuse), as assessed by subject history and a structured clinical interview (SCID-I/NP)
- Written informed consent
- Both genders and all ethnic origins, age between 18 and 45
- Right-handed
- Absence of any medications for at least 3 weeks
- Absence of pregnancy as determined by completion of a negative urine pregnancy test prior to the MRI scan
- Fluent English speaker
- Absence of current drug use (cocaine, cannabinoids, opiates, amphetamines, methamphetamines, phencyclidine, MDMA, benzodiazepines, methadone, oxycodone, tricyclic antidepressants, and barbiturates) as assessed by a urine drug test.
You may not qualify if…
- Pregnant or currently breast-feeding women or any woman of childbearing potential who is seeking to become pregnant or suspects that she may be pregnant.
- History or current serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease
- History of seizure disorder
- Failure to meet standard fMRI safety requirements
- History of head injury
- History or current diagnosis of any DSM-IV psychiatric illnesses; Presence of a DSM-IV psychiatric illness within a first-degree relative
- History of cocaine or stimulant use (e.g., amphetamine, cocaine, methamphetamine)
- History of use of dopaminergic drugs (including methylphenidate)
- History or current diagnosis of dementia
- Patients with mood congruent or mood incongruent psychotic features
- History or current use of any psychiatric medication
- Current use of any drug or herbal supplement with well-characterized psychotropic effects (e.g. St. John's wort)
- Clinical or laboratory evidence of hypothyroidism
- Diabetes with poor glucose control
- Currently taking medication that affects blood flow, e.g. certain blood pressure medications
- Evidence of significant inconsistencies in self-report.
Where it is running
- McLean Hospital — Belmont, Massachusetts, United States
Full record on ClinicalTrials.gov
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