Imaging Dopamine Function and Its Impact on Outcome After Traumatic Brain Injury (TBI)

Completed

Conditions studied: Traumatic Brain Injury

In brief

This study will examine resting dopamine function as well as dopamine response in the brain as it interacts with medicines normally prescribed to subacute Traumatic Brain Injury (TBI) patients.

Key facts

Study ID: NCT01850290
Run by: Baylor Research Institute
People needed: 18
Starts: 2013-05-01
Expected to finish: 2016-03-01
Last updated by the study team: 2018-02-05

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Non-penetrating TBI
Age between 18-50 years old
Admitted to a North Texas TBI Model Systems-affiliated rehabilitation facility within 16 weeks of injury
Rated at Rancho VI Los Amigos Levels of Cognitive Functioning Scale of less than or equal to Stage V at the time of enrollment
Disability Rating Scale total score >/= 7

You may not qualify if…

Central Nervous System disorder resulting in functional disability predating TBI
Documented diagnosis of disease processes impacted by the dopamine system (e.g., Parkinson's Disease, clinician diagnosed Attention Deficit Hyperactivity Disorder, substance abuse/dependence (excluding marijuana, alcohol, tobacco), or schizophrenia)
Pre-injury use of dopaminergic pharmaceuticals (i.e., methylphenidate, amantadine, or dopamine receptor blockers such as olanzapine or quetiapine)
Documented contraindication to use of methylphenidate including allergy
Uncontrolled epilepsy
Pregnant
Medical condition not compatible with use of Methylphenidate
Recent diagnosis or therapeutic study using radiopharmaceuticals
Contraindications to the use of Ioflupane
Allergic to Iodine

Where it is running

Baylor Research Institute — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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