Study of Dexmedetomidine in Spine Surgery

Completed · Phase 4

Conditions studied: Collapse of Thoracic Vertebra, Collapse of Lumbar Vertebrae

In brief

The investigators will conduct a prospective randomized double blind study comparing methadone plus methadone and intraoperative dexmedetomidine in multi-level spine surgery in two randomized groups. The investigators plan to document the intraoperative opioid requirements, time to first dose of opioids postoperatively and total opioid consumption in the first 24, 48 and 72 hours. The incidence of intra and postoperative complications will be assessed.

Key facts

Study ID

NCT01850017

Run by

University of Virginia

People needed

142

Starts

2012-08-01

Expected to finish

2015-05-01

Last updated by the study team

2017-05-05

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-80 years of age
• Elective multi-level thoracic and/or lumbar spine surgery requiring SSEP, EMG or MEP monitoring

You may not qualify if…

• Emergency spine surgery
• Age < 18 years
• Pregnant patients
• Advanced heart block: Mobitz type II block or atrio-ventricular dissociation in a previous EKG.
• Any individual with stage 4 or greater chronic kidney disease (eGFR< 30 ml/min) and/or requiring dialysis or liver failure defined as a history of cirrhosis or fulminant hepatic failure
• Any individuals on preoperative methadone therapy
• Preoperative dexmedetomidine use
• Preoperative systolic hypertension defined by a systolic blood pressure greater than 150 mmHg in the surgical admission suite
• Enrolled in another study within 30 days

Where it is running

• University of Virginia — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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