Effects Contrast on Platelet Activity, Thrombosis and Fibrinolysis in Patients Undergoing Coronary Angiography
Completed · Phase 4
Conditions studied: Coronary Artery Disease
In brief
The aim of this study is to determine how two different types of iodinated contrast media (CM) agents, low-osmolar ionic ioxaglate and iso-osmolar non-ionic iodixanol, affect specific markers of thrombogenesis and platelet function in patients undergoing coronary angiography, and if the use of bivalirudin, a direct thrombin inhibitor used during percutaneous coronary intervention (PCI), affects any contrast-related changes in thrombogenesis and platelet function.
Key facts
- Study ID
- NCT01848899
- Run by
- NYU Langone Health
- People needed
- 100
- Starts
- 2013-02-01
- Expected to finish
- 2014-11-01
- Last updated by the study team
- 2016-04-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients must be more than 18 years of age
- referred for coronary angiography and on dual anti-platelet therapy (aspirin and clopidogrel).
You may not qualify if…
- on warfarin
- on low molecular weight heparin within 12 hours of coronary angiography or unfractionated heparin with activated clotting time >150 at time of procedure -on cilostazol
- on persantine
- on non- steroidal anti-inflammatory medications (ibuprofen/motrin/advil, naproxen/aleve, indomethacin, sulindac, etodolac, diclofenac, celecoxib) within 72 hours of procedure
- on prasugrel (not an exclusion criteria for ST-segment elevation myocardial infarction registry
- undergoing coronary angiography via radial access
- undergoing planned diagnostic coronary angiography only
- unable to tolerate dual anti-platelet therapy
- with known allergy to CM
- received CM within 24 hours of coronary angiography
- on dialysis
- do not consent or are unable to give consent
- are participating in another competing study.
Where it is running
- New York University School of Medicine — New York, New York, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.