Effects of Estrogen Deficiency on Energy Expenditure

Completed · Not applicable

Conditions studied: Obesity

In brief

Menopause is associated with weight gain, but the reasons why are not clear. In this study, the investigators will determine if reducing estrogen levels causes a decrease in the ability of the body to produce heat. If so, this would suggest this is one way that menopause may cause weight gain.

Key facts

Study ID

NCT01846728

Run by

University of Colorado, Denver

People needed

6

Starts

2013-04-01

Expected to finish

2016-10-01

Last updated by the study team

2019-11-18

Who can join

Age: 20 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Body mass index < 30 kg/m2
• Normal menstrual cycles
• Premenopausal

You may not qualify if…

• irregular menstrual cycles defined as 2 or more missed cycles in the previous year
• on hormonal contraceptive or menopausal therapy
• positive pregnancy test
• intention to become pregnant or start hormonal contraceptive therapy during the period of study
• lactation
• severe osteopenia or osteoporosis (i.e., proximal femur or lumbar spine t scores < -2.0)
• abnormal vaginal bleeding
• thyroid dysfunction
• uncontrolled hypertension
• exercising at least 30 minutes per day at a moderate to vigorous intensity >1 d/wk) over the past 6 months

Where it is running

• University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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