Efficacy of Secretin MRCP in the Diagnosis and Follow up of Auto Immune Pancreatitis
Withdrawn before enrolling
Conditions studied: Cellular Diagnosis, Pancreatic Cancer, Autoimmune Pancreatitis
In brief
BACKGROUND: Auto immune pancreatitis (AIP), a benign pancreatic disease has certain morphological forms which mimics pancreatic malignancy in radiological appearance. There is no singe diagnostic test which can accurately differentiate these two conditions. In the past, AIP accounted for up to 27% of Whipple resections performed for suspected adenocarcinoma. AIMS: To evaluate the efficacy of Secretin assisted Magnetic resonance cholangio pancreatography (MRCP) in differentiating AIP and pancreatic malignancy. METHODS: 100 patients suspected with AIP will be consented to participate in the study to undergo secretin MRCP in addition to their other standard investigations. Patients will be categorized as those with AIP and with pancreatic malignancy based on these results and will be followed. Follow up will eventually give the true diagnosis when patients with pancreatic malignancy undergo pancreatic surgery and their pancreatic tissue is examined by histopathologist. AIP patients will undergo steroid trial which will give the true diagnosis. The preliminary diagnosis results based on standard investigations with and without inclusion of secretin MRCP will be compared to the true diagnosis.
Key facts
- Study ID
- NCT01845467
- Run by
- Johns Hopkins University
- People needed
- 0
- Starts
- 2013-02-01
- Expected to finish
- 2018-12-01
- Last updated by the study team
- 2019-01-10
Who can join
Age: 19 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female >18 years of age.
- Patients suspected of having AIP based on prior clinical work up
You may not qualify if…
- Unwilling or unable to give written, informed consent.
- Presence of pace makers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body.
- Patients with acute pancreatitis
Where it is running
- Johns Hopkins Hospital — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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